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pentobarbital will decrease the level or effect of imatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unknown.pentobarbital will lower the extent or influence of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib can be a delicate CYP3A4 substrate. Coadministration